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Open Access Articles- Top Results for Lecithin%E2%80%94cholesterol acyltransferase

Lecithin—cholesterol acyltransferase

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolLCAT
External IDsOMIM606967 MGI96755 HomoloGene68042 ChEMBL: 5942 GeneCards: LCAT Gene
EC number2.3.1.43
Orthologs
SpeciesHumanMouse
Entrez393116816
EnsemblENSG00000213398ENSMUSG00000035237
UniProtP04180P16301
RefSeq (mRNA)NM_000229NM_008490
RefSeq (protein)NP_000220NP_032516
Location (UCSC)Chr 16:
67.97 – 67.98 Mb
Chr 8:
105.94 – 105.94 Mb
PubMed search[1][2]

Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

See also

References

Further reading

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External links


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