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Open Access Articles- Top Results for Lesogaberan

Lesogaberan

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Lesogaberan
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IUPAC name
((R)-3-Amino-2-fluoropropyl)phosphinic acid
Other names
AZD-3355
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344413-67-8 7pxY=  7pxY
ChEMBL ChEMBL448343 7pxN
ChemSpider 23254384 7pxN
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C3H9FNO2P
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Infobox references

Lesogaberan (AZD-3355) was[1] an experimental drug candidate developed by AstraZeneca for the treatment of gastroesophageal reflux disease (GERD).[2] As a GABAB receptor agonist,[3] it has the same mechanism of action as baclofen, but is anticipated to have fewer of the central nervous system side effects that limit the clinical use of baclofen for the treatment of GERD.[4]

References

  1. ^ AstraZeneca. "AZD3355". Retrieved 30 December 2011. 
  2. ^ Bredenoord, Albert J. (2009). "Lesogaberan, a GABAB agonist for the potential treatment of gastroesophageal reflux disease". IDrugs 12 (9): 576–584. PMID 19697277. 
  3. ^ Alstermark; Amin, K; Dinn, SR; Elebring, T; Fjellström, O; Fitzpatrick, K; Geiss, WB; Gottfries, J et al. (2008). "Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors". Journal of Medicinal Chemistry 51 (14): 4315–4320. PMID 18578471. doi:10.1021/jm701425k. 
  4. ^ Brian E. Lacy, Robert Chehade, and Michael D. Crowell (2010). "Lesogaberan". Drugs of the Future 35 (12): 987–992. doi:10.1358/dof.2010.035.012.1540661. 


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