Open Access Articles- Top Results for Leukemia inhibitory factor receptor

Leukemia inhibitory factor receptor

SymbolsLIFR ; CD118; LIF-R; SJS2; STWS; SWS
External IDsOMIM151443 MGI96788 HomoloGene1735 IUPHAR: 1713 GeneCards: LIFR Gene
RNA expression pattern
File:PBB GE LIFR 205876 at tn.png
More reference expression data
RefSeq (mRNA)NM_001127671NM_001113386
RefSeq (protein)NP_001121143NP_001106857
Location (UCSC)Chr 5:
38.48 – 38.61 Mb
Chr 15:
7.13 – 7.2 Mb
PubMed search[1][2]

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.[1]


Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130.[2][3]

LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.

See also


  1. ^ "Entrez Gene: LIFR leukemia inhibitory factor receptor alpha". 
  2. ^ Timmermann, Andreas; Küster Andrea, Kurth Ingo, Heinrich Peter C, Müller-Newen Gerhard (Jun 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". Eur. J. Biochem. (Germany) 269 (11): 2716–26. ISSN 0014-2956. PMID 12047380. doi:10.1046/j.1432-1033.2002.02941.x. 
  3. ^ Mosley, B; De Imus C; Friend D; Boiani N; Thoma B; Park L S; Cosman D (Dec 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. (UNITED STATES) 271 (51): 32635–43. ISSN 0021-9258. PMID 8999038. doi:10.1074/jbc.271.51.32635. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Lua error in package.lua at line 80: module 'Module:Buffer' not found.