Open Access Articles- Top Results for Leukocyte receptor tyrosine kinase

Leukocyte receptor tyrosine kinase

SymbolsLTK ; TYK1
External IDsOMIM151520 MGI96840 HomoloGene130502 IUPHAR: 1838 ChEMBL: 5627 GeneCards: LTK Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE LTK 207106 s at tn.png
File:PBB GE LTK 217184 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001135685NM_008523
RefSeq (protein)NP_001129157NP_032549
Location (UCSC)Chr 15:
41.8 – 41.81 Mb
Chr 2:
119.75 – 119.76 Mb
PubMed search[1][2]

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[1][2]


The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]


LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[4][5]


  1. ^ Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res 5 (3): 199–204. PMID 2320375. 
  2. ^ a b "Entrez Gene: LTK leukocyte tyrosine kinase". 
  3. ^ Lopes SS, Yang X, Müller J, Carney TJ, McAdow AR, Rauch GJ et al. (2008). "Leukocyte tyrosine kinase functions in pigment cell development". PLoS Genet. 4 (3): e1000026. PMC 2265441. PMID 18369445. doi:10.1371/journal.pgen.1000026. 
  4. ^ Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (October 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene 9 (10): 2991–8. PMID 8084603. 
  5. ^ Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K et al. (June 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene 14 (25): 3067–72. PMID 9223670. doi:10.1038/sj.onc.1201153. 

Further reading