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Levobetaxolol

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Levobetaxolol
File:Levobetaxolol structure.svg
File:Levobetaxolol-fill.png
Systematic (IUPAC) name
(S)-1-[p-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol hydrochloride
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
  • US: C (Risk not ruled out)
topical (ophthalmic)
Pharmacokinetic data
Half-life 20 hours
Identifiers
93221-48-8 7pxN
None
PubChem CID 60657
ChemSpider 54669 7pxY
UNII 75O9XHA4TU 7pxY
ChEBI CHEBI:59254 7pxY
ChEMBL CHEMBL1201274 7pxN
Chemical data
Formula C18H29NO3
307.427 g/mol
 14pxN (what is this?)  (verify)

Levobetaxolol is a drug used to lower the pressure in the eye in treating conditions such as glaucoma. It is typically marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon. Levobetaxolol is a beta-adrenergic receptor inhibitor (beta blocker).

Effect

Levobetaxolol inhibits the beta-1-adrenergic receptor. When applied topically, it reduces intra-ocular pressure (IOP) by 16-23% depending on time of day and the individual. It is indicated for IOP reduction in patients with open-angle glaucoma or ocular hypertension. Levobetaxolol has fewer cardiovascular side effects than other beta blockers.

Contraindications and side effects

Levobetaxolol should not be used by people who have sinus bradycardia, atrioventricular block, cardiogenic shock, or overt cardiac failure.

The drug has been associated with bradycardia and hypertension.