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Lidoflazine

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Lidoflazine
File:Lidoflazine.png
Systematic (IUPAC) name
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
3416-26-0 7pxY
C08EX01
PubChem CID 3926
ChemSpider 3789 7pxN
UNII J4ZHN3HBTE 7pxY
KEGG D04733 7pxY
Chemical data
Formula C30H35F2N3O
491.615 g/mol
Physical data
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Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
 14pxN (what is this?)  (verify)

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties

Solubility at room temperature

Extracted from [2]

Solvent 0.01

N

0.1

N

 % pH  % pH
Hydrochloric Acid 0.4 3.0 0.7 1.9
Tartaric Acid 0.3 3.1 1.0 2.5
Citric Acid 0.3 3.1 0.5 2.5
Lactic Acid 0.2 3.4 0.7 2.9
Acetic Acid 0.1 3.5 0.4 3.8

References

  1. ^ Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. PMID 5944369. Retrieved 2009-06-20. 
  2. ^ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
  • Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 November 4;252(1):1-8.


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