Open Access Articles- Top Results for Liposarcoma


File:Myxoid liposarcoma (06).JPG
Micrograph of myxoid liposarcoma. H&E stain.
Classification and external resources
Specialty Oncology
ICD-O M8850/3
DiseasesDB 31482
eMedicine derm/856
NCI Liposarcoma
Patient UK Liposarcoma
MeSH D008080

Liposarcoma is a malignant tumor[1] that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum. Liposarcoma is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope.[2]

They are typically large bulky tumors which tend to have multiple smaller satellites extending beyond the main confines of the tumor.

Liposarcomas, like all sarcomas, are rare.[3]

Signs and symptoms

Photo of left leg edema caused by underlying liposarcoma

Patients usually note a deep seated mass in their soft tissue. Only when the tumor is very large do symptoms of pain or functional disturbances occur.

Retroperitoneal tumors may present themselves with signs of weight loss and emaciation and abdominal pain. These tumors may also compress the kidney or ureter leading to kidney failure.


File:Liposarcoma 02.jpg
CT image showing a lesion that proved to be a liposarcoma.
File:Dedifferentiated liposarcoma - intermed mag.jpg
Micrograph of a dedifferentiated liposarcoma. A dedifferentiated liposarcoma has a poorly differentiated component, that is not identifiable as a liposarcoma (left edge of image), and a differentiated component with lipoblasts and increased vascularity (right of image). Morphologically benign adipose tissue (center of image) has few blood vessels. H&E stain.

The diagnosis is established by histologic examination of the tissue, i.e. biopsy or excisional biopsy. Lipoblasts are often present; these are cells with an abundant clear multi-vacuolated cytoplasm and an eccentric darkly staining nucleus that is indented by the vacuoles.


Several subtypes of liposarcoma exist:

  • Well-differentiated liposarcoma, synonymous with atypical lipomatous tumor; the former term is used almost exclusively for lesions in the retroperitoneum, while the latter is used for lesions arising elsewhere.
  • Dedifferentiated liposarcoma, which consists of well-differentiated liposarcoma adjacent to a more poorly differentiated tumor.
  • Myxoid/round cell liposarcoma.
  • Pleomorphic liposarcoma.


The prognosis varies depending on the site of origin, the type of cancer cell, the tumor size, the depth, and proximity to lymph nodes. Well-differentiated liposarcomas treated with surgery and radiation have a low recurrence rate (about 10%) and rarely metastasize.[4] Five-year survival rates vary from 100% to 56% based on histological subtype.[4]


Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the second most common of all soft-tissue sarcomas following malignant fibrous histiocytomas. Annually 2.5 cases occur per million population.


The Wendy Walk is an organization devoted to funding research for liposarcoma.

See also


  1. ^ Dei Tos AP (August 2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol 4 (4): 252–66. PMID 10982304. doi:10.1053/adpa.2000.8133. 
  2. ^ Bell, Teresa (October 2012). "What is Liposarcoma?". The Liddy Shriver Sarcoma Initiative. Retrieved 2015-04-22. 
  3. ^ Goldstein-Rice, E (2008). "The Importance of Treatment at a Specialty Center for Sarcomas". ESUN. 
  4. ^ a b Gebhardt, M and Buecker, PJ (2004). "Liposarcoma". ESUN. 

External links