The Buffalo Bills Radio Network is flagshipped at WGR (AM 550). John Murphy is the team's current play-by-play announcer; he was a color commentator alongside and eventually succeeded longtime voice Van Miller after Miller's retirement at the end of the 2003 NFL season. Mark Kelso serves as the color analyst. The Bills radio network has seventeen affiliates in upstate New York and one affiliate, CJCL 590AM (The Fan) in Toronto.
- Paul Peck (?-2003, 2005-2008)
- Jeff Burris (2004-2005)
- Rich "Bull" Gaenzler (2009-2011)
- Joe Buscaglia (2012-2013)
- Sal Capaccio (2014-present)
- Jim Brinson (2004)
- Rich "Bull" Gaenzler (2005-2006)
- Vic Carucci (2006-2008)
- Brent Axe (2009-2011)
- Mike Schopp and Chris "Bulldog" Parker (2012-present)
During preseason, most games are televised on Buffalo's ABC affiliate, WKBW-TV channel 7, with several other affiliates in western New York. These games are simulcast on sister stations WTVH in Syracuse, WICU in Erie, WHAM-TV in Rochester, and beginning in 2008, CITY-TV in Toronto. Ray Bentley, a former Bills linebacker and current AFL on ESPN analyst, does play by play, while CBS analyst and former Bills special teams player Steve Tasker does color commentary on these games. WHAM-TV sports anchor Mike Catalana is the sideline reporter. Since 2008, preseason games have been broadcast in high definition.
In the event that regular season (or preseason) games are broadcast by a cable outlet (ESPN or NFL Network), WKBW-TV carries the ESPN or NFL Network feed, as required by the NFL (unless it is a non-sold out home game, which means the game is blacked out locally).