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Liver X receptor alpha

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Identifiers
SymbolsNR1H3 ; LXR-a; LXRA; RLD-1
External IDsOMIM602423 MGI1352462 HomoloGene21165 IUPHAR: 602 ChEMBL: 2808 GeneCards: NR1H3 Gene
RNA expression pattern
File:PBB GE NR1H3 203920 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1006222259
EnsemblENSG00000025434ENSMUSG00000002108
UniProtQ13133Q9Z0Y9
RefSeq (mRNA)NM_001130101NM_001177730
RefSeq (protein)NP_001123573NP_001171201
Location (UCSC)Chr 11:
47.27 – 47.29 Mb
Chr 2:
91.18 – 91.2 Mb
PubMed search[1][2]

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).[1][2]

Expression

miRNA hsa-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA hsa-miR-613.[3]

Function

The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs) and regulate expression of target genes containing LXR response elements.[4][5] Restoration of LXR-alpha expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin.[6]

Interactions

Liver X receptor alpha has been shown to interact with EDF1[7] and Small heterodimer partner.[8]

References

  1. ^ Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP (1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling". J. Biol. Chem. 271 (16): 9189–92. PMID 8621574. doi:10.1074/jbc.271.16.9189. 
  2. ^ Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ (1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway". Genes Dev. 9 (9): 1033–45. PMID 7744246. doi:10.1101/gad.9.9.1033. 
  3. ^ http://mend.endojournals.org/content/25/4/584.abstract
  4. ^ Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K (June 2009). "Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice". J. Clin. Invest. 119 (6): 1626–37. PMC 2689129. PMID 19436111. doi:10.1172/JCI35288. 
  5. ^ "Entrez Gene: nuclear receptor subfamily 1". 
  6. ^ Gupta DS, Kaul D, Kanwar AJ, Parsad D (January 2010). "Psoriasis: crucial role of LXR-alpha RNomics.". Genes and Immunity 11 (1): 37–44. doi:10.1038/gene.2009.63. 
  7. ^ Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. PMID 12040021. doi:10.1210/mend.16.6.0843. 
  8. ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. PMID 12198243. doi:10.1210/me.2001-0194. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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