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Open Access Articles- Top Results for Luteolin

Luteolin

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Luteolin
The chemical structure of luteolin
Ball-and-stick model of Luteolin
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IUPAC name
2-(3,4-Dihydroxyphenyl)- 5,7-dihydroxy-4-chromenone
Other names
Luteolol
Digitoflavone
Flacitran
Luteoline
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491-70-3 7pxY
ChEBI CHEBI:15864 7pxN
ChEMBL ChEMBL151 7pxN
ChemSpider 4444102 7pxN
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C15H10O6
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Luteolin is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance.[1]

Natural occurrences

Luteolin can be found in Terminalia chebula. It is most often found in leaves, but it is also seen in rinds, barks, clover blossom, and ragweed pollen.[1] It has also been isolated from the aromatic flowering plant, Salvia tomentosa in mint family Lamiaceae.[2]

Dietary sources include celery, broccoli, green pepper, parsley, thyme, dandelion, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, navel oranges, and oregano.[3][4] It can also be found in the seeds of the palm Aiphanes aculeata.[5]

Pharmacology

In vitro, luteolin activates the dopamine transporter.[6][7] Luteolin is under other preliminary laboratory research, but there is no evidence to date about its effects in humans.

Adverse effects

Gastrointestinal adverse effects, such as nausea, vomiting, and gastric hypersecretion, may occur, as shown in one animal study.[8] Luteolin has also been found to have adverse effects in laboratory studies with endometrial cancer cells by blocking endocrine effects of the hormone progesterone.[9]

Metabolism

These enzymes are part of luteolin metabolism:[citation needed]

Glycosides

References

  1. 1.0 1.1 Mann, John (1992). Secondary Metabolism (2nd ed.). Oxford, UK: Oxford University Press. pp. 279–280. ISBN 0-19-855529-6. 
  2. A. Ulubelen, M. Miski, P. Neuman, and T. J. Mabry (1979). "Flavonoids of Salvia tomentosa (Labiatae)". Journal of Natural Products 42 (4): 261–3. doi:10.1021/np50003a002. 
  3. Kayoko Shimoi, Hisae Okada, Michiyo Furugori, Toshinao Goda, Sachiko Takase, Masayuki Suzuki, Yukihiko Hara, Hiroyo Yamamoto, Naohide Kinae (1998). "Intestinal absorption of luteolin and luteolin 7-O-[beta]-glucoside in rats and humans". FEBS Letters 438 (3): 220–4. PMID 9827549. doi:10.1016/S0014-5793(98)01304-0. 
  4. López-Lázaro M. (2009). "Distribution and biological activities of the flavonoid luteolin". Mini Rev Med Chem. 9 (1): 31–59. PMID 19149659. doi:10.2174/138955709787001712. 
  5. Lee, D; Cuendet, M; Vigo, JS; Graham, JG; Cabieses, F; Fong, HH; Pezzuto, JM; Kinghorn, AD (2001). "A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata". Organic Letters 3 (14): 2169–71. PMID 11440571. doi:10.1021/ol015985j. 
  6. Zhao G, Qin GW, Wang J, Chu WJ, Guo LH (2010). "Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt". Neurochem. Int. 56 (1): 168–76. PMID 19815045. doi:10.1016/j.neuint.2009.09.015. 
  7. Zhang J, Liu X, Lei X et al. (2010). "Discovery and synthesis of novel luteolin derivatives as DAT agonists". Bioorg. Med. Chem. 18 (22): 7842–8. PMID 20971650. doi:10.1016/j.bmc.2010.09.049. 
  8. Yu, M. C.; Chen, J. H.; Lai, C. Y.; Han, C. Y.; Ko, W. C. (2010). "Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1–5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia". European Journal of Pharmacology 627 (1–3): 269–75. PMID 19853596. doi:10.1016/j.ejphar.2009.10.031.  edit
  9. "Common Autism Supplement Affects Endocrine System". Science Daily. July 15, 2013. Retrieved 2 September 2013. 
  10. Capanlar, S; Böke, N; Yaşa, I; Kirmizigül, S (2010). "A novel glycoside from Acanthus hirsutus (Acanthaceae)". Natural product communications 5 (4): 563–6. PMID 20433073.