Open Access Articles- Top Results for Lymphoblast
Journal of LeukemiaThymic Immunophenotype, and Expression of CD4 and Myeloid Antigens is Associated with Outcome in Adult Patients with Tï¿½Cell Acute Lymphoblastic Leuk
Journal of LeukemiaHigh Induction Response Rate, but Poor Long-Term Disease Free Survival in Elderly Patients Treated Aggressively for Acute Lymphoblastic Leukemia
Journal of LeukemiaProperties of the Bone Marrow Stromal Microenvironment in Adult Patients with Acute Lymphoblastic Leukemia before and After Allogeneic Transplantation
Journal of LeukemiaAre Survivors of Childhood Acute Lymphoblastic Leukemia at Increased Risk for Low Bone Mass?
Journal of Clinical & Experimental OphthalmologyUnilateral Optic Nerve Leukemic Infiltration and Exudative Retinal Detachment as Initial Manifestations of Central Nervous System Relapse in Acute Lym
A lymphoblast is a different form of a naive lymphocyte that occurs when the lymphocyte is activated by an antigen (from antigen-presenting cells) and increased in volume by nucleus and cytoplasm growth as well as new mRNA and protein synthesis. The lymphoblast then starts dividing and making clones of its original naive cells. Finally the dividing cells differentiate into effector cells, known as Plasma Cells (for B cells), Cytotoxic T cells, and Helper T cells.
Lymphoblasts are immature cells which typically differentiate to form mature lymphocytes. Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia (ALL), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood.
The size is between 10 and 20 μm.
Although commonly lymphoblast refers to a precursor cell in the maturation of leukocytes, the usage of this term is sometimes inconsistent. The Chronic Lymphocytic Leukemia Research Consortium defines a lymphoblast as "A lymphocyte that has become larger after being stimulated by an antigen. Lymphoblasts look like immature lymphocytes, and were once thought to be precursor cells.". Commonly, when speaking about leukemia, "blast" is used as an abbreviation for lymphoblasts.
Lymphoblasts can be distinguished microscopically from myeloblasts by having less distinct nucleoli, more condensed chromatin, and an absence of cytoplasmic granules. However these morphologic distinctions are not absolute and a definitive diagnoses relies on antibody immunostaining for the presence of unique cluster of differentiation receptors.
- Illu blood cell lineage.jpg
Blood cell lineage
- Janeway's Immunobiology, 8th edition, Chapter 1, page 22
- Gillian Rozenberg (23 March 2011). Microscopic Haematology: A Practical Guide for the Laboratory. Elsevier Australia. pp. 106–. ISBN 978-0-7295-4072-8. Retrieved 29 May 2011.
- CRC - Glossary L
- Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon C. (2010). Robbins and Cotran Pathologic Basis of Disease. Philadelphia: Saunders. p. 602. ISBN 978-1-4160-3121-5. 8th edition.
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