Open Access Articles- Top Results for MAFF (gene)

MAFF (gene)

SymbolsMAFF ; U-MAF; hMafF
External IDsOMIM604877 MGI96910 HomoloGene7825 GeneCards: MAFF Gene
RNA expression pattern
File:PBB GE MAFF 36711 at tn.png
File:PBB GE MAFF 205193 at tn.png
More reference expression data
RefSeq (mRNA)NM_001161572NM_010755
RefSeq (protein)NP_001155044NP_034885
Location (UCSC)Chr 22:
38.6 – 38.61 Mb
Chr 15:
79.35 – 79.36 Mb
PubMed search[1][2]

Transcription factor MafF is a protein that in humans is encoded by the MAFF gene.[1][2]

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.[2]

See also


  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031. 
  2. ^ a b "Entrez Gene: MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)". 

Further reading


External links

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