Open Access Articles- Top Results for MAFK


SymbolsMAFK ; NFE2U; P18
External IDsOMIM600197 MGI99951 HomoloGene1770 GeneCards: MAFK Gene
RefSeq (mRNA)NM_002360NM_010757
RefSeq (protein)NP_002351NP_034887
Location (UCSC)Chr 7:
1.57 – 1.58 Mb
Chr 5:
139.79 – 139.8 Mb
PubMed search[1][2]

Transcription factor MafK is a protein that in humans is encoded by the MAFK gene.[1][2]

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM][2]


  1. ^ Iwata T, Kogame K, Toki T, Yokoyama M, Yamamoto M, Ito E (Nov 1998). "Structure and chromosome mapping of the human small maf-genes MAFG and MAFK". Cytogenet Cell Genet 82 (1–2): 88–90. PMID 9763667. doi:10.1159/000015071. 
  2. ^ a b "Entrez Gene: MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)". 

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