Open Access Articles- Top Results for MAP2K2


SymbolsMAP2K2 ; MAPKK2; MEK2; MKK2; PRKMK2
External IDsOMIM601263 MGI1346867 HomoloGene48591 IUPHAR: 2063 ChEMBL: 2964 GeneCards: MAP2K2 Gene
EC number2.7.12.2
RNA expression pattern
File:PBB GE MAP2K2 202424 at tn.png
File:PBB GE MAP2K2 213490 s at tn.png
More reference expression data
RefSeq (mRNA)NM_030662.3NM_023138.4
RefSeq (protein)NP_109587.1NP_075627.2
Location (UCSC)Chr 19:
4.09 – 4.12 Mb
Chr 10:
80.57 – 80.59 Mb
PubMed search[1][2]

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[1]


The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[2]


MAP2K2 has been shown to interact with MAPK3[3][4][5] and ARAF.[6]


  1. ^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 11435–9. PMID 8388392. 
  2. ^ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2". 
  3. ^ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. (UNITED STATES) 272 (5): 2620–8. ISSN 0021-9258. PMID 9006895. doi:10.1074/jbc.272.5.2620. 
  4. ^ Butch, E R; Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. (UNITED STATES) 271 (8): 4230–5. ISSN 0021-9258. PMID 8626767. doi:10.1074/jbc.271.8.4230. 
  5. ^ Zheng, C F; Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. (UNITED STATES) 268 (32): 23933–9. ISSN 0021-9258. PMID 8226933. 
  6. ^ Yin, Xiang L; Chen She; Yan Jun; Hu Yun; Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta (Netherlands) 1589 (1): 71–6. ISSN 0006-3002. PMID 11909642. doi:10.1016/S0167-4889(01)00188-4. 

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