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Open Access Articles- Top Results for MAP3K1

MAP3K1

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Identifiers
SymbolsMAP3K1 ; MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
External IDsOMIM600982 MGI1346872 HomoloGene8056 IUPHAR: 2069 ChEMBL: 3956 GeneCards: MAP3K1 Gene
EC number2.7.11.25
RNA expression pattern
File:PBB GE MAP3K1 214786 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez421426401
EnsemblENSG00000095015ENSMUSG00000021754
UniProtQ13233P53349
RefSeq (mRNA)NM_005921NM_011945
RefSeq (protein)NP_005912NP_036075
Location (UCSC)Chr 5:
56.11 – 56.19 Mb
Chr 13:
111.75 – 111.81 Mb
PubMed search[1][2]

Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.[1][2]

MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM][2]

Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.

Interactions

MAP3K1 has been shown to interact with C-Raf,[3] MAPK8,[4] TRAF2,[5] MAP2K1,[3] Grb2,[6] MAPK1,[3] AXIN1[7][8] and UBE2I.[9]

References

  1. Vinik BS, Kay ES, Fiedorek FT Jr (April 1996). "Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5". Mamm Genome 6 (11): 782–3. PMID 8597633. doi:10.1007/BF00539003. 
  2. 2.0 2.1 "Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1". 
  3. 3.0 3.1 3.2 Karandikar, M; Xu S; Cobb M H (December 2000). "MEKK1 binds raf-1 and the ERK2 cascade components". J. Biol. Chem. (UNITED STATES) 275 (51): 40120–7. ISSN 0021-9258. PMID 10969079. doi:10.1074/jbc.M005926200. 
  4. Xu, S; Cobb M H (December 1997). "MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases". J. Biol. Chem. (UNITED STATES) 272 (51): 32056–60. ISSN 0021-9258. PMID 9405400. doi:10.1074/jbc.272.51.32056. 
  5. Baud, V; Liu Z G; Bennett B; Suzuki N; Xia Y; Karin M (May 1999). "Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain". Genes Dev. (UNITED STATES) 13 (10): 1297–308. ISSN 0890-9369. PMC 316725. PMID 10346818. doi:10.1101/gad.13.10.1297. 
  6. Pomérance, M; Multon M C; Parker F; Venot C; Blondeau J P; Tocqué B; Schweighoffer F (September 1998). "Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun–kinase activities in response to epidermal growth factor". J. Biol. Chem. (UNITED STATES) 273 (38): 24301–4. ISSN 0021-9258. PMID 9733714. doi:10.1074/jbc.273.38.24301. 
  7. Zhang, Yi; Qiu Wen-Jie; Chan Siu Chiu; Han Jiahuai; He Xi; Lin Sheng-Cai (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". J. Biol. Chem. (United States) 277 (20): 17706–12. ISSN 0021-9258. PMID 11884395. doi:10.1074/jbc.M111982200. 
  8. Zhang, Y; Neo S Y; Han J; Lin S C (August 2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. (UNITED STATES) 275 (32): 25008–14. ISSN 0021-9258. PMID 10829020. doi:10.1074/jbc.M002491200. 
  9. Saltzman, A; Searfoss G, Marcireau C, Stone M, Ressner R, Munro R, Franks C, D'Alonzo J, Tocque B, Jaye M, Ivashchenko Y (April 1998). "hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity". FEBS Lett. (NETHERLANDS) 425 (3): 431–5. ISSN 0014-5793. PMID 9563508. doi:10.1016/S0014-5793(98)00287-7. 

Further reading

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