Open Access Articles- Top Results for MAP3K10


SymbolsMAP3K10 ; MEKK10; MLK2; MST
External IDsOMIM600137 MGI1346879 HomoloGene1834 IUPHAR: 2070 ChEMBL: 2873 GeneCards: MAP3K10 Gene
EC number2.7.11.25
RNA expression pattern
File:PBB GE MAP3K10 206362 x at tn.png
More reference expression data
RefSeq (mRNA)NM_002446NM_001081292
RefSeq (protein)NP_002437NP_001074761
Location (UCSC)Chr 19:
40.7 – 40.72 Mb
Chr 7:
27.66 – 27.67 Mb
PubMed search[1][2]

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.[1][2][3]


The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.[3]


MAP3K10 has been shown to interact with:


  1. ^ Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR et al. (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem 234 (2): 492–500. PMID 8536694. doi:10.1111/j.1432-1033.1995.492_b.x. 
  2. ^ Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene 10 (7): 1447–51. PMID 7731697. 
  3. ^ a b "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10". 
  4. ^ a b Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T et al. (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. PMC 1170366. PMID 9427749. doi:10.1093/emboj/17.1.149. 
  5. ^ Liu YF, Dorow D, Marshall J (June 2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. PMID 10801775. doi:10.1074/jbc.C000180200. 
  6. ^ a b Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. PMC 84717. PMID 10490659. 
  7. ^ Marcora E, Gowan K, Lee JE (August 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9578–83. PMC 170960. PMID 12881483. doi:10.1073/pnas.1133382100. 

Further reading