Open Access Articles- Top Results for MAP3K7


SymbolsMAP3K7 ; MEKK7; TAK1; TGF1a
External IDsOMIM602614 MGI1346877 HomoloGene135715 IUPHAR: 2082 ChEMBL: 5776 GeneCards: MAP3K7 Gene
EC number2.7.11.25
RNA expression pattern
File:PBB GE MAP3K7 206854 s at tn.png
File:PBB GE MAP3K7 206853 s at tn.png
File:PBB GE MAP3K7 211536 x at tn.png
More reference expression data
RefSeq (mRNA)NM_003188NM_009316
RefSeq (protein)NP_003179NP_033342
Location (UCSC)Chr 6:
91.22 – 91.3 Mb
Chr 4:
31.96 – 32.02 Mb
PubMed search[1][2]

Mitogen-activated protein kinase kinase kinase 7 is an enzyme that in humans is encoded by the MAP3K7 gene.[1]


The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]


MAP3K7 has been shown to interact with:


  1. Kondo M, Osada H, Uchida K, Yanagisawa K, Masuda A, Takagi K et al. (February 1998). "Molecular cloning of human TAK1 and its mutational analysis in human lung cancer". Int J Cancer 75 (4): 559–63. PMID 9466656. doi:10.1002/(SICI)1097-0215(19980209)75:4<559::AID-IJC11>3.0.CO;2-4. 
  2. "Entrez Gene: MAP3K7 mitogen-activated protein kinase kinase kinase 7". 
  3. 3.0 3.1 Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J et al. (October 2000). "ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction". J. Biol. Chem. 275 (42): 32747–52. PMID 10921914. doi:10.1074/jbc.M003042200. 
  4. 4.0 4.1 4.2 4.3 Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature 398 (6724): 252–6. PMID 10094049. doi:10.1038/18465. 
  5. Sakurai H, Miyoshi H, Toriumi W, Sugita T (April 1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation". J. Biol. Chem. 274 (15): 10641–8. PMID 10187861. doi:10.1074/jbc.274.15.10641. 
  6. 6.0 6.1 Sakurai H, Miyoshi H, Mizukami J, Sugita T (June 2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Lett. 474 (2-3): 141–5. PMID 10838074. doi:10.1016/s0014-5793(00)01588-x. 
  7. 7.0 7.1 7.2 Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (December 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. PMC 291846. PMID 14633987. doi:10.1093/emboj/cdg605. 
  8. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ (July 2001). "TAK1 is a ubiquitin-dependent kinase of MKK and IKK". Nature 412 (6844): 346–51. PMID 11460167. doi:10.1038/35085597. 
  9. 9.0 9.1 9.2 Cheung PC, Nebreda AR, Cohen P (February 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. PMC 1223947. PMID 14670075. doi:10.1042/BJ20031794. 
  10. Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL et al. (November 2003). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. PMID 12975377. doi:10.1074/jbc.M306002200. 
  11. 11.0 11.1 Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K et al. (April 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol. Cell 5 (4): 649–58. PMID 10882101. doi:10.1016/s1097-2765(00)80244-0. 
  12. 12.0 12.1 Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (April 2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Mol. Cell. Biol. 21 (7): 2475–84. PMC 86880. PMID 11259596. doi:10.1128/MCB.21.7.2475-2484.2001. 
  13. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T (June 2000). "BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6". J. Biol. Chem. 275 (23): 17647–52. PMID 10748100. doi:10.1074/jbc.M908622199. 
  14. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M et al. (December 2001). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7". Genes Cells 6 (12): 1091–9. PMID 11737269. doi:10.1046/j.1365-2443.2001.00483.x. 
  15. Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R et al. (February 2001). "Regulation of the TAK1 signaling pathway by protein phosphatase 2C". J. Biol. Chem. 276 (8): 5753–9. PMID 11104763. doi:10.1074/jbc.M007773200. 
  16. Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y. Unutmaz D, ed. "TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL". PLoS ONE 3 (12): e4064. PMC 2603309. PMID 19112497. doi:10.1371/journal.pone.0004064. 
  17. Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N et al. (October 2008). "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner". Nat. Cell Biol. 10 (10): 1199–207. PMID 18758450. doi:10.1038/ncb1780. 

Further reading