Open Access Articles- Top Results for MAPK10


SymbolsMAPK10 ; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
External IDsOMIM602897 MGI1346863 HomoloGene56439 IUPHAR: 1498 ChEMBL: 2637 GeneCards: MAPK10 Gene
EC number2.7.11.24
RNA expression pattern
File:PBB GE MAPK10 204813 at tn.png
More reference expression data
RefSeq (mRNA)NM_002753NM_001081567
RefSeq (protein)NP_002744NP_001075036
Location (UCSC)Chr 4:
86.94 – 87.52 Mb
Chr 5:
102.91 – 103.21 Mb
PubMed search[1][2]

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.[1][2][3]


The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]


MAPK10 has been shown to interact with MAPK8IP3.[4][5][6]


  1. ^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B et al. (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J. 15 (11): 2760–70. PMC 450211. PMID 8654373. 
  2. ^ Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M (November 2002). "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene". J. Hum. Genet. 47 (11): 614–9. PMID 12436199. doi:10.1007/s100380200094. 
  3. ^ a b "Entrez Gene: MAPK10 mitogen-activated protein kinase 10". 
  4. ^ Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K et al. (November 1999). "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol. Cell. Biol. 19 (11): 7539–48. PMC 84763. PMID 10523642. 
  5. ^ Kelkar N, Gupta S, Dickens M, Davis RJ (February 2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. PMC 85220. PMID 10629060. doi:10.1128/MCB.20.3.1030-1043.2000. 
  6. ^ Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M et al. (October 2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43): 40703–9. PMID 12189133. doi:10.1074/jbc.M202004200. 

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