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Open Access Articles- Top Results for MAPK6

MAPK6

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Identifiers
SymbolsMAPK6 ; ERK3; HsT17250; PRKM6; p97MAPK
External IDsOMIM602904 MGI1354946 HomoloGene55683 IUPHAR: 2092 ChEMBL: 5121 GeneCards: MAPK6 Gene
EC number2.7.11.24
RNA expression pattern
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More reference expression data
Orthologs
SpeciesHumanMouse
Entrez559750772
EnsemblENSG00000069956ENSMUSG00000042688
UniProtQ16659Q61532
RefSeq (mRNA)NM_002748NM_015806
RefSeq (protein)NP_002739NP_056621
Location (UCSC)Chr 15:
52.24 – 52.36 Mb
Chr 9:
75.37 – 75.41 Mb
PubMed search[1][2]

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.[1][2]

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.[2]

References

  1. ^ Meloche S, Beatty BG, Pellerin J (Dec 1996). "Primary structure, expression and chromosomal locus of a human homolog of rat ERK3". Oncogene 13 (7): 1575–9. PMID 8875998. 
  2. ^ a b "Entrez Gene: MAPK6 mitogen-activated protein kinase 6". 

External links

Further reading

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