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Open Access Articles- Top Results for MAPKAPK5

MAPKAPK5

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Identifiers
SymbolsMAPKAPK5 ; MAPKAP-K5; MK-5; MK5; PRAK
External IDsOMIM606723 MGI1333110 HomoloGene69077 IUPHAR: 2096 ChEMBL: 3094 GeneCards: MAPKAPK5 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE MAPKAPK5 212871 at tn.png
File:PBB GE MAPKAPK5 gnf1h00042 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez855017165
EnsemblENSG00000089022ENSMUSG00000029454
UniProtQ8IW41O54992
RefSeq (mRNA)NM_003668NM_010765
RefSeq (protein)NP_003659NP_034895
Location (UCSC)Chr 12:
112.28 – 112.33 Mb
Chr 5:
121.52 – 121.55 Mb
PubMed search[1][2]

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.[1][2] The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.[2]

References

  1. ^ New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J (Jul 1998). "PRAK, a novel protein kinase regulated by the p38 MAP kinase". EMBO J 17 (12): 3372–84. PMC 1170675. PMID 9628874. doi:10.1093/emboj/17.12.3372. 
  2. ^ a b "Entrez Gene: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5". 

Further reading

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