Open Access Articles- Top Results for MAST2


SymbolsMAST2 ; MAST205; MTSSK
External IDsOMIM612257 MGI894676 HomoloGene7428 IUPHAR: 1511 GeneCards: MAST2 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE MAST2 211593 s at tn.png
File:PBB GE MAST2 215660 s at tn.png
File:PBB GE MAST2 215903 s at tn.png
More reference expression data
RefSeq (mRNA)NM_015112NM_001042743
RefSeq (protein)NP_055927NP_001036208
Location (UCSC)Chr 1:
46.25 – 46.5 Mb
Chr 4:
116.31 – 116.46 Mb
PubMed search[1][2]

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.[1] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.[2]


MAST2 has been shown to interact with PCLKC.[3]

Model organisms

Model organisms have been used in the study of MAST2 function. A conditional knockout mouse line called Mast2tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10]


  1. ^ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2". 
  2. ^ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. PMID 15308666. doi:10.1074/jbc.M404328200. 
  3. ^ Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. PMID 12117771. doi:10.1093/carcin/23.7.1139. 
  4. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  5. ^ a b "International Mouse Phenotyping Consortium". 
  6. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. PMC 3572410. PMID 21677750. doi:10.1038/nature10163. 
  7. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  8. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  9. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. PMID 23870131. doi:10.1016/j.cell.2013.06.022. 
  10. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading


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