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MELK

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Identifiers
SymbolsMELK ; HPK38
External IDsOMIM607025 MGI106924 HomoloGene32111 IUPHAR: 2102 ChEMBL: 4578 GeneCards: MELK Gene
EC number2.7.10.2, 2.7.11.1
RNA expression pattern
File:PBB GE MELK 204825 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez983317279
EnsemblENSG00000165304ENSMUSG00000035683
UniProtQ14680Q61846
RefSeq (mRNA)NM_001256685NM_010790
RefSeq (protein)NP_001243614NP_034920
Location (UCSC)Chr 9:
36.57 – 36.68 Mb
Chr 4:
44.3 – 44.36 Mb
PubMed search[1][2]

Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.[1][2][3]

Interactions

MELK has been shown to interact with CDC25B.[4]

References

  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. PMID 8724849. doi:10.1093/dnares/3.1.17. 
  2. ^ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev 47 (2): 148–56. PMID 9136115. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. 
  3. ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase". 
  4. ^ Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (Oct 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene 21 (50): 7630–41. PMID 12400006. doi:10.1038/sj.onc.1205870. 

Further reading

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