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Open Access Articles- Top Results for MNT (gene)

MNT (gene)

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Identifiers
SymbolsMNT ; MAD6; MXD6; ROX; bHLHd3
External IDsOMIM603039 MGI109150 HomoloGene7842 GeneCards: MNT Gene
RNA expression pattern
File:PBB GE MNT 204206 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez433517428
EnsemblENSG00000070444ENSMUSG00000000282
UniProtQ99583O08789
RefSeq (mRNA)NM_020310NM_010813
RefSeq (protein)NP_064706NP_034943
Location (UCSC)Chr 17:
2.29 – 2.3 Mb
Chr 11:
74.83 – 74.85 Mb
PubMed search[1][2]

Max-binding protein MNT is a protein that in humans is encoded by the MNT gene.[1][2]

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.[2]

Interactions

MNT (gene) has been shown to interact with MLX,[3][4] SIN3A[5] and MAX.[5]

References

  1. Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (August 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics 49 (2): 275–282. PMID 9598315. doi:10.1006/geno.1998.5241. 
  2. 2.0 2.1 "Entrez Gene: MNT MAX binding protein". 
  3. Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–627. ISSN 0964-6906. PMID 11230181. doi:10.1093/hmg/10.6.617. 
  4. Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–3277. ISSN 0950-9232. PMID 10918583. doi:10.1038/sj.onc.1203634. 
  5. 5.0 5.1 Meroni, G; Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter D H, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. (ENGLAND) 16 (10): 2892–2906. ISSN 0261-4189. PMC 1169897. PMID 9184233. doi:10.1093/emboj/16.10.2892. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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