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Open Access Articles- Top Results for MT-ATP8

MT-ATP8

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Identifiers
SymbolsATP8 ; ATPase8; MTATP8
External IDsOMIM516070 HomoloGene124425 IUPHAR: GeneCards: ATP8 Gene
Orthologs
SpeciesHumanMouse
Entrez4509n/a
EnsemblENSG00000228253n/a
UniProtP03928n/a
RefSeq (mRNA)n/an/a
RefSeq (protein)n/an/a
Location (UCSC)Chr MT:
0.01 – 0.01 Mb
n/a
PubMed search[1]n/a
ATP synthase protein 8 (metazoa)
Identifiers
Symbol ATP-synt_8
Pfam PF00895
Pfam clan CL0255
InterPro IPR001421
Plant ATP synthase F0 subunit 8
Identifiers
Symbol YMF19
Pfam PF02326
Pfam clan CL0255
InterPro IPR003319
Fungal ATP synthase protein 8 (A6L)
Identifiers
Symbol Fun_ATP-synt_8
Pfam PF05933
Pfam clan CL0255
InterPro IPR009230

ATP synthase protein 8 is an protein that in humans is encoded by the MT-ATP8 gene. It is a subunit of mitochondrial ATP synthase.

This subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases.[1] The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa. Subunit 8 differs in sequence between Metazoa, plants and fungi).


References

  1. ^ Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ (May 2003). "The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification". J. Biol. Chem. 278 (20): 17867–75. PMID 12626501. doi:10.1074/jbc.M300967200. 

Further reading

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This article incorporates text from the public domain Pfam and InterPro IPR001421


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