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Open Access Articles- Top Results for MTF1

MTF1

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Identifiers
SymbolsMTF1 ; MTF-1; ZRF
External IDsOMIM600172 MGI101786 HomoloGene4347 GeneCards: MTF1 Gene
RNA expression pattern
File:PBB GE MTF1 205323 s at tn.png
File:PBB GE MTF1 205322 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez452017764
EnsemblENSG00000188786ENSMUSG00000028890
UniProtQ14872Q07243
RefSeq (mRNA)NM_005955NM_008636
RefSeq (protein)NP_005946NP_032662
Location (UCSC)Chr 1:
38.28 – 38.33 Mb
Chr 4:
124.8 – 124.85 Mb
PubMed search[1][2]

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[1][2]

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[2]

References

  1. Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W (Sep 1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1". Nucleic Acids Res 22 (15): 3167–73. PMC 310292. PMID 8065932. doi:10.1093/nar/22.15.3167. 
  2. 2.0 2.1 "Entrez Gene: MTF1 metal-regulatory transcription factor 1". 

Further reading

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External links


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