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MXD4

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Identifiers
SymbolsMXD4 ; MAD4; MST149; MSTP149; bHLHc12
External IDsMGI104991 HomoloGene4712 GeneCards: MXD4 Gene
RNA expression pattern
File:PBB GE MXD4 212346 s at tn.png
File:PBB GE MXD4 210778 s at tn.png
File:PBB GE MXD4 212347 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1060817122
EnsemblENSG00000123933ENSMUSG00000037235
UniProtQ14582Q60948
RefSeq (mRNA)NM_006454NM_010753
RefSeq (protein)NP_006445NP_034883
Location (UCSC)Chr 4:
2.25 – 2.26 Mb
Chr 5:
34.17 – 34.19 Mb
PubMed search[1][2]

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[1][2]

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[2]

References

Further reading

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