Open Access Articles- Top Results for MYCL1


SymbolsMYCL ; LMYC; MYCL1; bHLHe38
External IDsOMIM164850 MGI96799 HomoloGene3921 GeneCards: MYCL Gene
RNA expression pattern
File:PBB GE MYCL1 214058 at tn.png
File:PBB GE MYCL1 215491 at tn.png
More reference expression data
RefSeq (mRNA)NM_001033081NM_008506
RefSeq (protein)NP_001028253NP_032532
Location (UCSC)Chr 1:
40.36 – 40.37 Mb
Chr 4:
123 – 123 Mb
PubMed search[1][2]

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]


MYCL1 has been shown to interact with MAX.[4][5]


  1. ^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190. PMID 8978772. doi:10.1159/000134185. 
  2. ^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)". 
  3. ^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. 
  4. ^ Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science 251 (4998): 1211–1217. PMID 2006410. doi:10.1126/science.2006410. 
  5. ^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L et al. (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. PMID 10229200. doi:10.1038/sj.onc.1202611. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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