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MYLK

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Identifiers
SymbolsMYLK ; AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK
External IDsOMIM600922 MGI894806 HomoloGene14202 IUPHAR: 1552 ChEMBL: 2428 GeneCards: MYLK Gene
EC number2.7.11.18
RNA expression pattern
File:PBB GE MYLK 202555 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez4638107589
EnsemblENSG00000065534ENSMUSG00000022836
UniProtQ15746B1B1A8
RefSeq (mRNA)NM_005965NM_139300
RefSeq (protein)NP_444253NP_647461
Location (UCSC)Chr 3:
123.33 – 123.6 Mb
Chr 16:
34.75 – 35 Mb
PubMed search[1][2]

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.[1]

Function

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.[2]

See also

References

  1. ^ Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG (Mar 1996). "The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21". Genomics 29 (3): 562–70. PMID 8575746. doi:10.1006/geno.1995.9965. 
  2. ^ "Entrez Gene: MYLK myosin, light chain kinase". 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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