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MYLK3

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Identifiers
SymbolsMYLK3 ; MLCK; MLCK2; caMLCK
External IDsOMIM612147 MGI2443063 HomoloGene35278 IUPHAR: 2110 ChEMBL: 4627 GeneCards: MYLK3 Gene
EC number2.7.11.18
Orthologs
SpeciesHumanMouse
Entrez91807213435
EnsemblENSG00000140795ENSMUSG00000031698
UniProtQ32MK0Q3UIZ8
RefSeq (mRNA)NM_182493NM_001297612
RefSeq (protein)NP_872299NP_001284541
Location (UCSC)Chr 16:
46.74 – 46.82 Mb
Chr 8:
85.32 – 85.39 Mb
PubMed search[1][2]

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.[1][2]

Function

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.[3]

See also

References

  1. ^ "Entrez Gene: MLCK MLCK protein". 
  2. ^ Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. PMC 1978424. PMID 17885681. doi:10.1172/JCI30804. 
  3. ^ Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008). "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. PMC 2504503. PMID 18202317. doi:10.1161/CIRCRESAHA.107.161687. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.Template:Gene-16-stub