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Open Access Articles- Top Results for MYO10

MYO10

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Identifiers
SymbolsMYO10 ; FLJ10639; FLJ21066; FLJ22268; FLJ43256; KIAA0799; MGC131988
External IDsOMIM601481 MGI107716 HomoloGene36328 GeneCards: MYO10 Gene
RNA expression pattern
File:PBB GE MYO10 201976 s at tn.png
File:PBB GE MYO10 216222 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez465117909
EnsemblENSG00000145555ENSMUSG00000022272
UniProtQ9HD67F8VQB6
RefSeq (mRNA)NM_012334NM_019472
RefSeq (protein)NP_036466NP_062345
Location (UCSC)Chr 5:
16.67 – 16.94 Mb
Chr 15:
25.62 – 25.81 Mb
PubMed search[1][2]

Myosin X, also known as MYO10, is a protein that in humans is encoded by the MYO10 gene.[1][2][3]

Myosin X is an actin-based motor protein known to associate at the tips of filopodia.[4]

Model organisms

Model organisms have been used in the study of MYO10 function. A conditional knockout mouse line called Myo10tm2(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute [5]. Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]

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References

  1. ^ "Entrez Gene: MYO10 myosin X". 
  2. ^ Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (July 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6549–53. PMC 44240. PMID 8022818. doi:10.1073/pnas.91.14.6549. 
  3. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics 36 (3): 431–9. PMID 8884266. doi:10.1006/geno.1996.0488. 
  4. ^ Berg JS, Cheney RE (March 2002). "Myosin-X is an unconventional myosin that undergoes intrafilopodial motility". Nature Cell Biology 4 (3): 246–50. PMID 11854753. doi:10.1038/ncb762. 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. PMC 3572410. PMID 21677750. doi:10.1038/nature10163. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. PMID 23870131. doi:10.1016/j.cell.2013.06.022. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading

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