Malignancy - Related Links
Open Access Articles- Top Results for Malignancy
Pancreatic Disorders & TherapyAcute Pancreatitis is a Predictive Factor for Malignancy in Mixed or Main Duct Intraductal Papillary Mucinous Neoplasms
Journal of Clinical Case ReportsTuberculosis of Breast Masquerading as Malignancy
Journal of Carcinogenesis & MutagenesisHypereosinophilia Induced by Lung Adenocarcinoma: A Rare Case
Oral Health and Dental ManagementMeasurement of the Total Number of Bacteria in Saliva Using Quantitative Real-Time PCR During Treatment for Head and Neck Malignancy: A Series of Case
Journal of Hematology & Thromboembolic DiseasesHypercoagulability in Malignancy and a Rare Case of Embolıc Stroke as a Consequence of Nonbacterial Thrombotic Endocarditis in Ovarian Clear Cel
Malignancy (from Latin male, meaning "badly", and -gnus, meaning "born") is the tendency of a medical condition to become progressively worse.
Malignancy is most familiar as a characterization of cancer. A malignant tumor contrasts with a non-cancerous benign tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign tumor has none of those properties.
Malignancy in cancers is characterized by anaplasia, invasiveness, and metastasis. Malignant tumors are also characterized by genome instability, so that cancers, as assessed by whole genome sequencing, frequently have between 10,000 and 100,000 mutations in their entire genomes. Cancers usually show tumour heterogeneity, containing multiple subclones. They also frequently have reduced expression of DNA repair enzymes due to epigenetic methylation of DNA repair genes or altered microRNAs that control DNA repair gene expression.
Uses of "malignant" in oncology:
- Malignancy, malignant neoplasm and malignant tumor are synonymous with cancer
- Malignant ascites
- Malignant transformation
Non-oncologic disorders referred to as "malignant":
- Malignant hypertension
- Malignant hyperthermia
- Malignant otitis externa
- Malignant tertian malaria (malaria caused specifically by Plasmodium falciparum)
- Neuroleptic malignant syndrome
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- Wilkins, E. M. 2009. clinical practice of the dental hygienist tenth edition. lippincott williams and wilkins, a walters kluwer business. Philadelphia, PA.
- Tuna M, Amos CI (November 2013). "Genomic sequencing in cancer". Cancer Lett. 340 (2): 161–70. PMID 23178448. doi:10.1016/j.canlet.2012.11.004.
- Swanton C (October 2012). "Intratumor heterogeneity: evolution through space and time". Cancer Res. 72 (19): 4875–82. PMC 3712191. PMID 23002210. doi:10.1158/0008-5472.CAN-12-2217.
- Sabaawy HE (November 2013). "Genetic Heterogeneity and Clonal Evolution of Tumor Cells and their Impact on Precision Cancer Medicine". J Leuk (Los Angel) 1 (4): 1000124. PMC 3927925. PMID 24558642. doi:10.4172/2329-6917.1000124.
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