Open Access Articles- Top Results for Meclofenoxate


Systematic (IUPAC) name
2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Clinical data
AHFS/ International Drug Names
51-68-3 7pxY
PubChem CID 4039
ChemSpider 3899 7pxN
KEGG D00993 7pxY
Chemical data
Formula C12H16ClNO3
 14pxN (what is this?)  (verify)

Meclofenoxate (Lucidril), also known as centrophenoxine, is a drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition.[1] Meclofenoxate also increases cellular membrane phospholipids.[citation needed]

It is also used off-label as a nootropic.

Side effects and contraindications

Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate.[2][unreliable source?] Large doses may cause tight jaw clenching.

See also


  1. ^ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing 6 (2): 123–31. PMID 329662. doi:10.1093/ageing/6.2.123. 
  2. ^ Centrophenoxine Page @ The American Academy of Anti-Aging Medicine

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