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Open Access Articles- Top Results for Meclonazepam

Meclonazepam

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Meclonazepam
File:Meclonazepam structure.svg
Systematic (IUPAC) name
(3S)-5-(2-Chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Clinical data
Identifiers
58662-84-3 7pxN
None
PubChem CID 3033985
ChemSpider 2298544 7pxY
UNII RN43209SMA 7pxY
ChEMBL CHEMBL351821 7pxN
Chemical data
Formula C16H12ClN3O3
329.74
 14pxN (what is this?)  (verify)

Meclonazepam[1] ((S)-3-methylclonazepam) was discovered by a team at Hoffmann-La Roche in the 1970s and is a drug which is a benzodiazepine derivative similar in structure to clonazepam.[2] It has sedative and anxiolytic actions like those of other benzodiazepines,[3] and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.[4]

See also

References

  1. ^ U.S. Patent 4,031,078
  2. ^ The Lundbeck Institute. "Meclonazepam". Psychotropics. Lundbeck. 
  3. ^ Ansseau, M.; Doumont, A.; Thiry, D.; Von Frenckell, R.; Collard, J. (1985). "Initial study of methylclonazepam in generalized anxiety disorder. Evidence for greater power in the cross-over design". Psychopharmacology 87 (2): 130–135. PMID 3931136. doi:10.1007/bf00431795.  edit
  4. ^ O'Boyle, C.; Lambe, R.; Darragh, A. (1985). "Central Effects in Man of the Novel Schistosomicidal Benzodiazepine Meclonazepam". European Journal of Clinical Pharmacology 29 (1): 105–108. PMID 4054198. doi:10.1007/bf00547377.  edit

Further reading

  • Abdul-Ghani, R. A.; Loutfy, N.; Hassan, A. (2009). "Experimentally promising antischistosomal drugs: A review of some drug candidates not reaching the clinical use". Parasitology Research 105 (4): 899–906. PMID 19588166. doi:10.1007/s00436-009-1546-2.  edit


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