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Open Access Articles- Top Results for Medifoxamine

Medifoxamine

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Medifoxamine
File:Medifoxamine Structural Formulae.png
Systematic (IUPAC) name
N,N-dimethyl-2,2-diphenoxyethanamine
Clinical data
  • (Prescription only)
Oral
Identifiers
32359-34-5 7pxY
N06AX13
PubChem CID 36109
ChemSpider 33212
UNII KWU7C2A1NT 7pxY
KEGG D07341 7pxY
Chemical data
Formula C16H19NO2
257.328 g/mol
 14pxY (what is this?)  (verify)

Medifoxamine (Cledial, Gerdaxyl) is an antidepressant which acts as a dopamine reuptake inhibitor[1] and agonist at the 5-HT2A and 5-HT2C receptors.[2] It was used mainly in France,[3] but was withdrawn following problems with hepatotoxicity.[4]

References

  1. ^ Saleh, S.; Turner, P. (1992). "Ocular hypotensive effects of medifoxamine". British Journal of Clinical Pharmacology 34 (3): 269–271. PMC 1381400. PMID 1389953. doi:10.1111/j.1365-2125.1992.tb04136.x. 
  2. ^ Martin, P.; Lemonnier, F. (1994). "Intérêt des récepteurs sérotoninergiques de type 2, 5-HT2A et 5-HT2C, dans les troubles dépressifs : action de la médifoxamine" [The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: Effect of medifoxamine]. L'Encéphale (in French) 20 (4): 427–435. PMID 7988407. 
  3. ^ Mitchell, P. B. (1995). "Novel French antidepressants not available in the United States". Psychopharmacology Bulletin 31 (3): 509–519. PMID 8668756. 
  4. ^ Dumortier, G.; Cabaret, W.; Stamatiadis, L.; Saba, G.; Benadhira, R.; Rocamora, J. F.; Aubriot-Delmas, B.; Glikman, J.; Januel, D. (2002). "Tolérance hépatique des antipsychotiques atypiques" [Hepatic tolerance of atypical antipsychotic drugs]. L'Encéphale (in French) 28 (6 Pt 1): 542–551. PMID 12506267. 


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