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Open Access Articles- Top Results for Mephenytoin

Mephenytoin

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Mephenytoin
Structural formula of mephenytoin
Space-filling model of the mephenytoin molecule
Systematic (IUPAC) name
5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a611020
  • US: C (Risk not ruled out)
Oral
Pharmacokinetic data
Half-life 7 hours
Identifiers
50-12-4 7pxY
N03AB04
PubChem CID 4060
DrugBank DB00532 7pxY
ChemSpider 3920 7pxY
UNII R420KW629U 7pxY
KEGG D00375 7pxY
ChEMBL CHEMBL861 7pxY
Chemical data
Formula C12H14N2O2
218.252
 14pxY (what is this?)  (verify)

Mephenytoin (marketed as Mesantoin by Novartis) is a hydantoin, used as an anticonvulsant. It was introduced approximately 10 years after phenytoin, in the late 1940s. The significant metabolite of mephenytoin is nirvanol (5-ethyl-5-phenylhydantoin), which was the first hydantoin (briefly used as a hypnotic). However, nirvanol is quite toxic and mephenytoin was only considered after other less toxic anticonvulsants had failed. It can cause potentially fatal blood dyscrasia in 1% of patients.

Mephenytoin is no longer available in the US or the UK. It is still studied largely because of its interesting hydroxylation polymorphism.

References


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