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Metaraminol

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Metaraminol
File:Metaraminol Structural Formulae.png
Systematic (IUPAC) name
(1R,2S)-3-[-2-amino-1-hydroxy-propyl]phenol
Clinical data
AHFS/Drugs.com International Drug Names
  • AU: C
  • US: C (Risk not ruled out)
Intravenous
Pharmacokinetic data
Bioavailability n/a
Protein binding ~45%
Metabolism Hepatic
Identifiers
54-49-9 7pxY
33402-03-8 (bitartrate)
C01CA09
PubChem CID 5906
DrugBank DB00610 7pxY
ChemSpider 5695 7pxY
UNII 818U2PZ2EH 7pxY
KEGG D08192 7pxY
ChEBI CHEBI:6794 7pxY
ChEMBL CHEMBL1201319 7pxN
Chemical data
Formula C9H13NO2
167.205 g/mol
 14pxN (what is this?)  (verify)

Metaraminol (INN; trade names Aramine, Metaramin, and Pressonex), also known as metaradrine, a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist with some β effect.[1]

Metaraminol is also used in the treatment of priapism. Although not approved for this use, it appears to be effective.[2][3][4]

See also

References

  1. Kee VR. Hemodynamic pharmacology of intravenous vasopressors. Crit Care Nurse. 2003 Aug;23(4):79-82. PMID 12961786
  2. McDonald M, Santucci R (2004). "Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol.". Int Braz J Urol 30 (2): 121–2. PMID 15703094. doi:10.1590/S1677-55382004000200007. 
  3. Koga S, Shiraishi K, Saito Y (1990). "Post-traumatic priapism treated with metaraminol bitartrate: case report.". J Trauma 30 (12): 1591–3. PMID 2258979. doi:10.1097/00005373-199012000-00029. 
  4. Block T, Sturm W, Ernst G, Staehler G, Schmiedt E (1988). "[Metaraminol in therapy of various forms of priapism]". Urologe A 27 (4): 225–9. PMID 3140463. 


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