Open Access Articles- Top Results for Methdilazine


Systematic (IUPAC) name
10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine
Clinical data
AHFS/ monograph
1982-37-2 7pxY
PubChem CID 14677
DrugBank DB00902 7pxY
ChemSpider 14009 7pxY
UNII 4Q13LY9Z8X 7pxY
KEGG D04979 7pxY
ChEMBL CHEMBL1200959 7pxN
Chemical data
Formula C18H20N2S
296.431 g/mol
 14pxN (what is this?)  (verify)

Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.


File:Methdilazine synthesis.png
Methdilazine synthesis:[1] R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; U.S. Patent 2,945,855 (1960).

See also


  1. ^ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959). R. F. Feldkamp and Y. H. Wu,
  • Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res 160 (1): 95–100. PMID 15782943. doi:10.1016/j.micres.2004.10.002. 
  • Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother 42 (1): 83–6. PMID 9700532. doi:10.1093/jac/42.1.83. 
  • Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung 38 (7): 869–72. PMID 2905130. 

The ring-contracted analog, methdilazine, interestingly enough shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.

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