|Systematic (IUPAC) name|
Methoxphenidine (methoxyphenidine, MXP, 2-MXP, 2-MeO-Diphenidine) is a dissociative drug that has been sold online as a research chemical. Methoxphenidine was first reported in a 1989 patent where it was tested as a treatment for neurotoxic injury. Shortly after the 2013 UK ban on arylcyclohexylamines methoxphenidine and the related compound diphenidine became available on the gray market, where it has been encountered as a powder and in tablet form. Though diphenidine possesses higher affinity for the NMDA receptor, anecdotal reports suggest methoxphenidine has greater oral potency. Of the three isomeric anisyl-substituents methoxphenidine has affinity for the NMDA receptor that is higher than 4-MeO-diphenidine but lower than 3-MeO-diphenidine, a structure–activity relationship shared by the anisylcyclohexylamines.
Acute methoxphenidine intoxication has been reported to produce confusion, hypertension, and tachycardia that was responsive to treatment with intravenous lorazepam, methoxphenidine has also been associated with three published fatalities.
- Morris, H.; Wallach, J. (2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis 6: 614–632. doi:10.1002/dta.1620.
- EP patent 0346791, Gray NM, Cheng BK, "1,2-diarylethylamines for treatment of neurotoxic injury", assigned to G.D. Searle & Co.
- McLaughlin, G.; Morris, N.; Kavanagh, P.; Power, J.; O'Brien, J.; Talbot, B.; Elliott, S.; Wallach, J.; Hoang, K.; Morris, H.; Brandt, S. (2015). "Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers". Drug Testing and Analysis. doi:10.1002/dta.1800.
- Hofer, K.E.; Degrandi, C.; Müller, D.M.; Zürrer-Härdi, U.; Wahl, S.; Rauber-Lüthy, C.; Ceschi, A. (2014). "Acute toxicity associated with the recreational use of the novel dissociative psychoactive substance methoxphenidine". Clinical Toxicology 52: 1288–1291. doi:10.3109/15563650.2014.974264.
- Elliott, S.P.; Brandt, S.D.; Wallach, J.; Morris, H.; Kavanagh, S. (2015). "First Reported Fatalities Associated with the ‘Research Chemical’ 2-Methoxydiphenidine". Analytical Toxicology.
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