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Open Access Articles- Top Results for Metrifonate

Metrifonate

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Metrifonate
200px
Systematic (IUPAC) name
(RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Half-life 3 hours
Identifiers
52-68-6 7pxY
P02BB01 QP52AB01 QP53AF02
PubChem CID 5853
ChemSpider 5644
UNII DBF2DG4G2K 7pxY
KEGG C07971 7pxY
ChEBI CHEBI:6908 7pxY
Synonyms Trichlorphon
Chemical data
Formula C4H8Cl3O4P
257.436 g/mol
 14pxY (what is this?)  (verify)

Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor.[1] It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.[3]

References

  1. "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease". 
  2. Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine 346 (16): 1212–1220. PMID 11961151. doi:10.1056/NEJMra012396. 
  3. López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. PMID 16625573. doi:10.1002/14651858.CD003155.pub3. 

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