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Microscopic colitis

Microscopic colitis
File:Collagenous colitis - intermed mag.jpg
Micrograph of collagenous colitis, a type of microscopic colitis. H&E stain.
Classification and external resources
ICD-10 K52.8
ICD-9 558.9
DiseasesDB 30087
eMedicine med/1351
NCI Microscopic colitis
Patient UK Microscopic colitis
MeSH D046728

Microscopic colitis refers to two medical conditions which cause diarrhea: collagenous colitis and lymphocytic colitis. Both conditions are characterised by the following triad of clinicopathological features:

  1. Chronic watery diarrhea;
  2. Normal colonoscopy;
  3. Characteristic histopathology (inflammatory cells).

Clinical features

Patients are characteristically, though not exclusively, middle-aged females. They present with a long history of watery diarrhoea, which may be profuse. There is a higher incidence of autoimmune diseases, for example arthritis, Sjögren's syndrome, and coeliac disease, in patients with microscopic colitis. There are reports of associations with multiple drugs, especially proton pump inhibitors, H2 blockers, and non-steroidal anti-inflammatory drugs (NSAIDs).

Colonoscopy is normal or near normal. The changes are often patchy, so multiple colonic biopsies must be taken in order to make the diagnosis.[citation needed] A full colonoscopy is required, as an examination limited to the rectum will miss cases of microscopic colitis.


The hallmark of microscopic colitis is an increase in inflammatory cells (i.e., lymphocytes) in colonic biopsies with an otherwise normal appearance and architecture of the colon. Inflammatory cells are increased both in the surface epithelium ("intraepithelial lymphocytes") and in the lamina propria. In lymphocytic colitis, these are the only abnormal features.

In collagenous colitis, the features of lymphocytic colitis are present, with, in addition, the presence of a thickened subepithelial collagen layer which may be up to 30 micrometres thick.


No single treatment is accepted as the standard, and measuring response is difficult. Often a trial of anti-diarrhoeals is followed by anti-inflammatory drugs.

Lymphocytic colitis is thought to respond well to bismuth subsalicylate (Pepto-Bismol) and mesalazine and collagenous colitis to respond well to budesonide.[1]


The prognosis for lymphocytic colitis and collagenous colitis is good, and both conditions are considered to be benign.[2] The majority of people afflicted with the conditions recover from their diarrhea, and their histological abnormalities resolve.[1]

See also


  1. ^ a b Fernández-Bañares F, Salas A, Esteve M, Espinós J, Forné M, Viver J (2003). "Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up.". Am J Gastroenterol 98 (2): 340–7. PMID 12591052. doi:10.1111/j.1572-0241.2003.07225.x. 
  2. ^ Mullhaupt B, Güller U, Anabitarte M, Güller R, Fried M (1998). "Lymphocytic colitis: clinical presentation and long term course". Gut 43 (5): 629–33. PMC 1727313. PMID 9824342. doi:10.1136/gut.43.5.629. 

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