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Minaprine

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Minaprine
File:Minaprine.svg
Systematic (IUPAC) name
4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
Clinical data
AHFS/Drugs.com International Drug Names
  • (Prescription only)
Oral
Pharmacokinetic data
Half-life 2-2.5 hours
Identifiers
25905-77-5 7pxY
N06AX07
PubChem CID 4199
ChemSpider 4054 7pxN
UNII 00U7GX0NLM 7pxN
KEGG D05039 7pxY
ChEMBL CHEMBL278819 7pxN
Chemical data
Formula C17H22N4O
298.383 g/mol
 14pxN (what is this?)  (verify)

Minaprine (Brantur, Cantor) is an antidepressant that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.[1]

A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats.[2] In a study it has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.[3]

See also

References

  1. ^ Fung, M.; Thornton, A.; Mybeck, K.; Wu, J. H.-h.; Hornbuckle, K.; Muniz, E. (1 January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science 35 (1): 293–317. doi:10.1177/009286150103500134. 
  2. ^ Kan JP, Mouget-Goniot C, Worms P, Biziere K (1986). "Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat". Biochemical Pharmacology 35 (6): 973–978. PMID 3954800. doi:10.1016/0006-2952(86)90085-7. 
  3. ^ Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG (1999). "Aminopyridazines as acetylcholinesterase inhibitors". Journal of Medicinal Chemistry 42 (4): 730–741. PMID 10052979. doi:10.1021/jm981101z. 

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