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Open Access Articles- Top Results for Monocarboxylate transporter 1

Monocarboxylate transporter 1

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Identifiers
SymbolsSLC16A1 ; HHF7; MCT; MCT1
External IDsOMIM600682 MGI106013 HomoloGene20662 IUPHAR: 988 ChEMBL: 4360 GeneCards: SLC16A1 Gene
RNA expression pattern
File:PBB GE SLC16A1 202236 s at tn.png
File:PBB GE SLC16A1 202234 s at tn.png
File:PBB GE SLC16A1 202235 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez656620501
EnsemblENSG00000155380ENSMUSG00000032902
UniProtP53985P53986
RefSeq (mRNA)NM_001166496NM_009196
RefSeq (protein)NP_001159968NP_033222
Location (UCSC)Chr 1:
113.45 – 113.5 Mb
Chr 3:
104.64 – 104.66 Mb
PubMed search[1][2]

Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene (also known as MCT1).[1][2][3] It is a proton coupled monocarboxylate transporter.

Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism. MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. The protein then undergoes a conformational change to a new ‘closed’’ conformation that exposes both the proton and lactate to the opposite surface of the membrane where they are released, lactate first and then the proton. For net transport of lactic acid, the rate-limiting step is the return of MCT1 without bound substrate to the open conformation. For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane.

See also

References

  1. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell 76 (5): 865–73. PMID 8124722. doi:10.1016/0092-8674(94)90361-1. 
  2. ^ Garcia CK, Li X, Luna J, Francke U (Sep 1994). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12". Genomics 23 (2): 500–3. PMID 7835905. doi:10.1006/geno.1994.1532. 
  3. ^ "Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)". 

Further reading

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