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Monocarboxylate transporter 2

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Identifiers
SymbolsSLC16A7 ; MCT2
External IDsOMIM603654 HomoloGene20990 IUPHAR: 990 GeneCards: SLC16A7 Gene
Orthologs
SpeciesHumanMouse
Entrez919420503
EnsemblENSG00000118596ENSMUSG00000020102
UniProtO60669O70451
RefSeq (mRNA)NM_001270622NM_011391
RefSeq (protein)NP_001257551NP_035521
Location (UCSC)Chr 12:
59.6 – 59.79 Mb
Chr 10:
125.23 – 125.33 Mb
PubMed search[1][2]

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.[1] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.

See Also

References

  1. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell 76 (5): 865–73. PMID 8124722. doi:10.1016/0092-8674(94)90361-1. 

Further Reading

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