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Open Access Articles- Top Results for Monocarboxylate transporter 3

Monocarboxylate transporter 3

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Identifiers
SymbolsSLC16A8 ; MCT3; REMP
External IDsOMIM610409 HomoloGene75006 IUPHAR: 991 GeneCards: SLC16A8 Gene
Orthologs
SpeciesHumanMouse
Entrez2353957274
EnsemblENSG00000100156ENSMUSG00000032988
UniProtO95907O35308
RefSeq (mRNA)NM_013356NM_020516
RefSeq (protein)NP_037488NP_065262
Location (UCSC)Chr 22:
38.08 – 38.08 Mb
Chr 15:
79.25 – 79.25 Mb
PubMed search[1][2]

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.[1] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

References

  1. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell 76 (5): 865–73. PMID 8124722. doi:10.1016/0092-8674(94)90361-1. 

Further Reading

  • Yoon H, Donoso LA, Philp NJ (1999). "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics 60 (3): 366–70. PMID 10493836. doi:10.1006/geno.1999.5926. 
  • Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. PMID 12657613. doi:10.1167/iovs.02-0287. 
  • Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. PMID 15917240. doi:10.1074/jbc.M411950200. 
  • Cori CF (1981). "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul. 18: 377–87. PMID 7273846. 
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflugers Arch. 447 (5): 619–28. PMID 12739169. doi:10.1007/s00424-003-1067-2. 
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