Open Access Articles- Top Results for Motilin receptor

Motilin receptor

SymbolsMLNR ; GPR38; MTLR1
External IDsOMIM602885 HomoloGene74398 IUPHAR: 297 ChEMBL: 2203 GeneCards: MLNR Gene
RNA expression pattern
File:PBB GE MLNR 221365 at tn.png
More reference expression data
RefSeq (mRNA)NM_001507n/a
RefSeq (protein)NP_001498n/a
Location (UCSC)Chr 13:
49.79 – 49.8 Mb
PubMed search[1]n/a

Motilin receptor is a G protein-coupled receptor that binds motilin.[1][2] Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle.


  1. ^ Depoortere I (2001). "Motilin and motilin receptors: characterization and functional significance". Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29. PMID 11813507. 
  2. ^ Yang X, Dong L, Yang H (2006). "[Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]". Sichuan Da Xue Xue Bao Yi Xue Ban (in Chinese) 37 (5): 683–6. PMID 17037727. 

Further reading

  • Smith RG, Leonard R, Bailey AR et al. (2001). "Growth hormone secretagogue receptor family members and ligands.". Endocrine 14 (1): 9–14. PMID 11322507. doi:10.1385/ENDO:14:1:009. 
  • McKee KK, Tan CP, Palyha OC et al. (1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.". Genomics 46 (3): 426–34. PMID 9441746. doi:10.1006/geno.1997.5069. 
  • Feighner SD, Tan CP, McKee KK et al. (1999). "Receptor for motilin identified in the human gastrointestinal system.". Science 284 (5423): 2184–8. PMID 10381885. doi:10.1126/science.284.5423.2184. 
  • Miller P, Roy A, St-Pierre S et al. (2000). "Motilin receptors in the human antrum.". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18–23. PMID 10644557. 
  • Thielemans L, Depoortere I, Van Assche G et al. (2001). "Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.". Brain Res. 895 (1–2): 119–28. PMID 11259768. doi:10.1016/S0006-8993(01)02055-8. 
  • Coulie B, Matsuura B, Dong M et al. (2001). "Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling". J. Biol. Chem. 276 (38): 35518–22. PMID 11461914. doi:10.1074/jbc.M104489200. 
  • Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). "The motilin pharmacophore in CHO cells expressing the human motilin receptor". Biochem. Biophys. Res. Commun. 293 (4): 1223–7. PMID 12054506. doi:10.1016/S0006-291X(02)00356-X. 
  • Depoortere I, Thijs T, Thielemans L et al. (2003). "Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum". J. Pharmacol. Exp. Ther. 305 (2): 660–7. PMID 12606621. doi:10.1124/jpet.102.047563. 
  • Dunham A, Matthews LH, Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. PMC 2665288. PMID 15057823. doi:10.1038/nature02379. 
  • Matsuura B, Dong M, Naik S et al. (2006). "Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity". J. Biol. Chem. 281 (18): 12390–6. PMID 16531413. doi:10.1074/jbc.M511921200. 

External links

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