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Multilobular tumour of bone

The Multilobular tumour of bone (MTB), although uncommon, is the most common tumour of the canine skull.

MTB usually presents as a firm, circumscribed and generally slowgrowing bone tumour in older dogs from medium or large breeds. Its biological behaviour may range from benign to malignant, as it has the potential to invade, metastasise and recur.[1][2] Histologically, it is characterised by the dominant presence of multiple osteoid- or cartilage- containing lobules that are separated by fibrous septae.[3][4] MTB should be differentiated from other bone tumours.[5] Although most frequently found in dogs,[6] MTB has been reported in humans,[7] cats,[8] a horse and a ferret.[9] The clinical signs depend on the tumour location. Depending on its location and stage in the clinical course, surgical resection may result in long-term remission.[10]


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  2. ^ Straw RC, LeCouteur RA, Powers BE, Withrow SJ. Multilobular osteochondrosarcoma of the canine skull: 16 cases (1978-1988). J Am Vet Med Assoc 1989, 195, 1764-1769
  3. ^ Slayter MV, Boosinger TR, Pool RR, Dammrich K, Misdorp W, Larsen S. Histological Classification of Bone and Joint Tumors of Domestic Animals. pp. 1-50, Armed Forces Institute of Pathology, Washington DC, 1994
  4. ^ Thompson KG, Pool RR. Tumors of bones. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 296-298, Iowa State University Press, Ames, 2002
  5. ^ Loukopoulos P, Thornton JR , Robinson WF. Clinical and pathologic relevance of p53 index in canine osseous tumors. Veterinary Pathology 2003; 40:237-248.
  6. ^ Psychas V, Loukopoulos P, Polizopoulou ZS , Sofianidis G. Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog. J Vet Sci 2009; 10:81-83
  7. ^ Jacobson SA. The Comparative Pathology of the Tumors of Bone. pp. 102-109, Thomas, Springfield, 1971
  8. ^ Rossetti E, Bertolini G, Zotti A. Multilobular tumour of bone of the thoracic wall in a cat. J Feline Med Surg 2007, 9, 254-257
  9. ^ Hanley CS, Gieger T, Frank P. What is your diagnosis? Multilobular osteoma (MLO). J Am Vet Med Assoc 2004, 225, 1665-1666
  10. ^ Dernell WS, Straw RC, Cooper MF, Powers BE, LaRue SM, Withrow SJ. Multilobular osteochondrosarcoma in 39 dogs: 1979-1993. J Am Anim Hosp Assoc 1998, 34, 11-18