Myopathy - Related Links
Open Access Articles- Top Results for Myopathy
Journal of Clinical & Experimental CardiologyA Case of Symptomatic Hypertrophic Cardiomyopathy with Severe Dynamic Gradient
Gynecology & ObstetricsMaternal Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome and Neonatal Magnesium Toxicity: A Case Report
Journal of Molecular Biomarkers & DiagnosisRyanodine Receptor Mutation in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Clinical Implications
Journal of Clinical & Experimental CardiologyPosterolateral Hypokinesia Slight Circumflex Artery Stenosis or Mid-Ventricular Takotsubo Cardiomyopathy?
Epidemiology: Open AccessA Case of Neuromyopathy Due to Synthetic Antimalarial Drugs
|Classification and external resources|
In medicine, a myopathy is a muscular disease in which the muscle fibers do not function for any one of many reasons, resulting in muscular weakness. "Myopathy" simply means muscle disease (myo- Greek μυο "muscle" + pathos -pathy Greek "suffering"). This meaning implies that the primary defect is within the muscle, as opposed to the nerves ("neuropathies" or "neurogenic" disorders) or elsewhere (e.g., the brain etc.). Muscle cramps, stiffness, and spasm can also be associated with myopathy.
Capture Myopathy, or Shock Disease, is a little-studied condition observed in wild animals such as hares and birds that have been captured or handled. The condition is usually lethal and stress has been identified as the single most determining factor, exacerbated by muscle exertion.
Myopathy in systemic diseases
Myopathies in systemic disease results from several different disease processes including endocrine, inflammatory, paraneoplastic, infectious, drug- and toxin-induced, critical illness myopathy, metabolic, and myopathies with other systemic disorders. Patients with systemic myopathies often present acutely or sub acutely. On the other hand, familial myopathies or dystrophies generally present in a chronic fashion with exceptions of metabolic myopathies where symptoms on occasion can be precipitated acutely. Most of the inflammatory myopathies can have a chance association with malignant lesions; the incidence appears to be specifically increased only in patients with dermatomyositis.
There are many types of myopathy. ICD-10 codes are provided here where available.
- (G71.0) Dystrophies (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. Clinically, muscular dystrophies are typically progressive, because the muscles' ability to regenerate is eventually lost, leading to progressive weakness, often leading to use of a wheelchair, and eventually death, usually related to respiratory weakness.
- (G71.1) Myotonia
- (G71.2) The congenital myopathies do not show evidence for either a progressive dystrophic process (i.e., muscle death) or inflammation, but instead characteristic microscopic changes are seen in association with reduced contractile ability of the muscles. Congenital myopathies include, but are not limited to:
- (G71.2) nemaline myopathy (characterized by presence of "nemaline rods" in the muscle),
- (G71.2) multi/minicore myopathy (characterized by multiple small "cores" or areas of disruption in the muscle fibers),
- (G71.2) centronuclear myopathy (or myotubular myopathy) (in which the nuclei are abnormally found in the center of the muscle fibers), a rare muscle wasting disorder
- (G71.3) Mitochondrial myopathies, which are due to defects in mitochondria, which provide a critical source of energy for muscle
- (G72.3) Familial periodic paralysis
- (G72.4) Inflammatory myopathies, which are caused by problems with the immune system attacking components of the muscle, leading to signs of inflammation in the muscle
- (G73.6) Metabolic myopathies, which result from defects in biochemical metabolism that primarily affect muscle
- (G72.0 - G72.2) External substance induced myopathy
- Dermatomyositis produces muscle weakness and skin changes. The skin rash is reddish and most commonly occurs on the face, especially around the eyes, and over the knuckles and elbows. Ragged nail folds with visible capillaries can be present. It can often be treated by drugs like corticosteroids or immunosuppressants. (M33.2)
- Polymyositis produces muscle weaknesss. It can often be treated by drugs like corticosteroids or immunosuppressants.
- Inclusion body myositis is a slowly progressive disease that produces weakness of hand grip and straightening of the knees. No effective treatment is known.
- (M61) Myositis ossificans
- (M62.89) Rhabdomyolysis and (R82.1) myoglobinurias
The Food and Drug Administration is recommending that physicians restrict prescribing high-dose Simvastatin (Zocor, Merck) to patients, given an increased risk of muscle damage. The FDA drug safety communication stated that physicians should limit using the 80-mg dose unless the patient has already been taking the drug for 12 months and there is no evidence of myopathy. "Simvastatin 80 mg should not be started in new patients, including patients already taking lower doses of the drug," the agency states.
Differential diagnosis of systemic myopathy based on age of onset
Myopathies presenting at birth:- None as systemic causes; mainly hereditary
Myopathies presenting in childhood:-
Inflammatory myopathies – dermatomyositis, polymyositis (rarely)
Endocrine and metabolic disorders – hypokalemia, hypocalcemia, hypercalcemia
Myopathies presenting in adulthood
Inflammatory myopathies – polymyositis, dermatomyositis, inclusion body myositis, viral (HIV)
Endocrine myopathies – thyroid, parathyroid, adrenal, pituitary disorders
Toxic myopathies – alcohol, corticosteroids, narcotics, colchicines, chloroquine
Critical illness myopathy
Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptoms to very specific cause-targeting treatments. Drug therapy, physical therapy, bracing for support, surgery, and massage are all current treatments for a variety of myopathies.
- "Myopathy - Definition from the Merriam-Webster Online Dictionary".
- Rendle, M. (2006). "Stress and Capture Myopathy in Hares" (PDF). Irish Hare Initiative. Retrieved 2013-09-15.
- Chawla, Jasvinder (2011). "Stepwise Approach to Myopathy in Systemic Disease". Frontiers in Neurology (Front Neurol. 2011; 2: 49) 2: 49. PMC 3153853. PMID 21886637. doi:10.3389/fneur.2011.00049.
- Seene T (July 1994). "Turnover of skeletal muscle contractile proteins in glucocorticoid myopathy". J. Steroid Biochem. Mol. Biol. 50 (1–2): 1–4. PMID 8049126. doi:10.1016/0960-0760(94)90165-1.
- Chawla, Myopathy (2011). "Systemic Myopathy". Frontiers in Neurology 2: 49. PMC 3153853. PMID 21886637. doi:10.3389/fneur.2011.00049.
- GeneReviews/NCBI/NIH/UW entry on Myopathy with Deficiency of ISCU
- See http://neuromuscular.wustl.edu/ for medical descriptions.