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Open Access Articles- Top Results for N-Desalkylflurazepam

N-Desalkylflurazepam

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Systematic (IUPAC) name
7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Clinical data
  • Not FDA approved
Identifiers
2886-65-9
PubChem CID 4540
ChemSpider 4381
ChEMBL CHEMBL974
Synonyms Dealkylflurazepam, Desalkylflurazepam, Descarbethoxyloflazepate, N-1-Desalkylflurazepam, N-Desalkyl-2-oxoquazepam, N-Desalkylflutoprazepam, Norfludiazepam, Norflurazepam, Norflutoprazepam, Ro 5-3367
Chemical data
Formula C15H10ClFN2O
288.70 g/mol
Physical data
Melting point Script error: No such module "convert". [1]

N-Desalkylflurazepam is an active metabolite of several benzodiazepine drugs including flurazepam,[2] flutoprazepam,[3] fludiazepam,[4] midazolam,[5] quazepam,[6] and ethyl loflazepate.[7][8] It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes.[6]

References

  1. ^ SciFinder record for CAS#2886-65-9
  2. ^ Riva, Roberto; De Anna, Marco; Albani, Fiorenzo; Baruzzi, Agostino (1981). "Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas—liquid chromatography with electron-capture detection". Journal of Chromatography B: Biomedical Sciences and Applications 222 (3): 491. doi:10.1016/S0378-4347(00)84153-5. 
  3. ^ Barzaghi, N; Leone, L; Monteleone, M; Tomasini, G; Perucca, E (1989). "Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects". European journal of drug metabolism and pharmacokinetics 14 (4): 293–8. PMID 2633923. 
  4. ^ J. Descotes, ed. (1996). Human Toxicology. p. 43. 
  5. ^ Vogt, Susanne; Kempf, Jürgen; Buttler, Jürgen; Auwärter, Volker; Weinmann, Wolfgang (2013). "Desalkylflurazepam found in patients' samples after high-dose midazolam treatment". Drug Testing and Analysis 5 (9–10): 745. PMID 23713025. doi:10.1002/dta.1484. 
  6. ^ a b Nikaido, AM; Ellinwood Jr, EH (1987). "Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance". Psychopharmacology 92 (4): 459–64. PMID 2888152. doi:10.1007/bf00176478. 
  7. ^ B. B. Ba, A. Iliadis, J. P. Cano; Iliadis; Cano (1989). "Pharmacokinetic modeling of ethyl loflazepate (VictanR) and its main active metabolites". Annals of Biomedical Engineering 17 (6): 633–646. PMID 2574017. 
  8. ^ Davi, H.; Guyonnet, J.; Necciari, J.; Cautreels, W. (1985). "Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: Comparison with solvent extraction and thin-layer chromatography". Journal of Chromatography B: Biomedical Sciences and Applications 342: 159. doi:10.1016/S0378-4347(00)84498-9.