Open Access Articles- Top Results for N-Methyltryptamine


Systematic (IUPAC) name
Clinical data
61-49-4 7pxN
PubChem CID 6088
ChemSpider 5863 7pxY
KEGG C06213 7pxY
ChEBI CHEBI:28136 7pxY
ChEMBL CHEMBL348588 7pxY
Chemical data
Formula C11H14N2
174.245 g/mol
Physical data
Melting point Script error: No such module "convert".
 14pxN (what is this?)  (verify)

N-Methyltryptamine (NMT), or methyltryptamine, is a member of the tryptamine chemical class. It is an alkaloid, probably derived from L-tryptophan, that has been found in the bark, shoots and leaves of several plant species, including Virola, Acacia, Mimosa and Desmanthus often together with the related compounds N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).[1] It is also synthesized in the human body as a metabolic endproduct of the amino acid L-tryptophan.[2] It was found to be a natural trace component in human urine.[3]

Orally administered NMT appears to produce no psychoactive effects, likely as a result of extensive first-pass metabolism.[4] However, it may become active upon combination with a MAOA inhibitor (MAOI).[4] By vaporization NMT shows activity at 50–100 mg, with a duration of 45–70 minutes; duration of visual effects 15–30 seconds. Effects are primarily non-visual.[5][6]

NMT has been shown to act as an agonist of the TAAR1, similarly to its relatives tryptamine and N,N-dimethyltryptamine.[7]

See also


  1. ^ see wikipedia list of psychedlic plants for references
  2. ^ Tryptophan metabolism
  3. ^ Scand J Clin Lab Invest. 2001;61(7):547-56. Determination of potentially hallucinogenic N-dimethylated indoleamines in human urine by HPLC/ESI-MS-MS. Forsström T, Tuominen J, Karkkäinen J.
  4. ^ a b Foye's principles of medicinal chemistry By William O. Foye, Thomas L. Lemke, David A. Williams
  5. ^ Shulgin & Shulgin "TIKHAL" 1997
  6. ^ Nen 2011 - lecture presented EGA conference, Victoria. 4/12/2011.
  7. ^ Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological Sciences 26 (5): 274–81. PMID 15860375. doi:10.1016/ 

External links