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Open Access Articles- Top Results for N6-Cyclopentyladenosine

N6-Cyclopentyladenosine

N6-Cyclopentyladenosine
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IUPAC name
(2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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41552-82-3 7pxY
ChemSpider 571479 7pxN
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C15H21N5O4
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Infobox references

N6-Cyclopentyladenosine (CPA) is a drug which acts as a selective adenosine A1 receptor agonist.[1] It has mainly cardiovascular effects with only subtle alterations of behavior.[2] CPA is widely used in scientific research into the adenosine receptors and has been used to derive a large family of derivatives.[3][4][5][6][7]

See also

References

  1. ^ Williams M, Braunwalder A, Erickson TJ (February 1986). "Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue". Naunyn-Schmiedeberg's Archives of Pharmacology 332 (2): 179–183. PMID 3703020. doi:10.1007/BF00511410. 
  2. ^ Coffin VL, Spealman RD (April 1987). "Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys". The Journal of Pharmacology and Experimental Therapeutics 241 (1): 76–83. PMID 3572798. 
  3. ^ Zablocki JA, Wu L, Shryock J, Belardinelli L (2004). "Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF)". Current Topics in Medicinal Chemistry 4 (8): 839–854. PMID 15078215. doi:10.2174/1568026043450998. 
  4. ^ Hutchinson SA, Scammells PJ (2004). "A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential". Current Pharmaceutical Design 10 (17): 2021–2039. PMID 15279543. doi:10.2174/1381612043384204. 
  5. ^ Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J (January 2007). "N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists". Bioorganic & Medicinal Chemistry Letters 17 (1): 161–166. PMID 17045477. doi:10.1016/j.bmcl.2006.09.065. 
  6. ^ Elzein E, Zablocki J (December 2008). "A1 adenosine receptor agonists and their potential therapeutic applications". Expert Opinion on Investigational Drugs 17 (12): 1901–1910. PMID 19012505. doi:10.1517/13543780802497284. 
  7. ^ Franchetti P, Cappellacci L, Vita P, Petrelli R, Lavecchia A, Kachler S, Klotz KN, Marabese I, Luongo L, Maione S, Grifantini M (April 2009). "N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice". Journal of Medicinal Chemistry 52 (8): 2393–2406. PMID 19317449. doi:10.1021/jm801456g. 



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